Out of many, IL-1.
Immunity 59(3) 521-523
Selected Publications
Recent and foundational work from the Wheeler Lab
A PubMed-backed index of Wheeler Lab publications, refreshed automatically as new records appear.
Papers from our lab
Papers led by the Wheeler Lab.
Immune-brain plasticity underpins stress and affective behaviors.
Neuron 114(1) 9-32
Psychedelic control of neuroimmune interactions governing fear.
Nature 641(8065) 1276-1286
The neuroimmune connectome in health and disease.
Nature 638(8050) 333-342
Interactions between immune cells recorded.
Nature 627(8003) 277-279
Astrocytes on steroids binge on synapses to cope with stress.
Immunity 56(9) 1983-1985
Droplet-based forward genetic screening of astrocyte-microglia cross-talk.
Science (New York, N.Y.) 379(6636) 1023-1030
Microglia and Central Nervous System-Associated Macrophages-From Origin to Disease Modulation.
Annual review of immunology 39 251-277
MAFG-driven astrocytes promote CNS inflammation.
Nature 578(7796) 593-599
Environmental Control of Astrocyte Pathogenic Activities in CNS Inflammation.
Cell 176(3) 581-596.e18
Regulation of Astrocyte Functions in Multiple Sclerosis.
Cold Spring Harbor perspectives in medicine 9(1)
Control of immune-mediated pathology via the aryl hydrocarbon receptor.
The Journal of biological chemistry 292(30) 12383-12389
Genetically targeted magnetic control of the nervous system.
Nature neuroscience 19(5) 756-761
Collaborative work
Work with close collaborators.
Integrative neuroimmunology reveals leukocyte-expressing PAX6 as a critical predictor of major depressive disorder.
Translational psychiatry 16(1) 35
Barcoded viral tracing identifies immunosuppressive astrocyte-glioma interactions.
Nature 644(8078) 1097-1106
Glioblastoma-instructed astrocytes suppress tumour-specific T cell immunity.
Nature 643(8070) 219-229
CLEC16A in astrocytes promotes mitophagy and limits pathology in a multiple sclerosis mouse model.
Nature neuroscience 28(3) 470-486
Droplet-based functional CRISPR screening of cell-cell interactions by SPEAC-seq.
Nature protocols 20(2) 440-461
FIND-seq: high-throughput nucleic acid cytometry for rare single-cell transcriptomics.
Nature protocols 19(11) 3191-3218
Disease-associated astrocyte epigenetic memory promotes CNS pathology.
Nature 627(8005) 865-872
The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology.
Nature immunology 25(3) 432-447
Lactate limits CNS autoimmunity by stabilizing HIF-1α in dendritic cells.
Nature 620(7975) 881-889
Multiple sclerosis: Neuroimmune crosstalk and therapeutic targeting.
Cell 186(7) 1309-1327
HIV silencing and cell survival signatures in infected T cell reservoirs.
Nature 614(7947) 318-325
Identification of astrocyte regulators by nucleic acid cytometry.
Nature 614(7947) 326-333
Identification of environmental factors that promote intestinal inflammation.
Nature 611(7937) 801-809
Function and therapeutic value of astrocytes in neurological diseases.
Nature reviews. Drug discovery 21(5) 339-358
Protocol for inducing inflammation and acute myelin degeneration in larval zebrafish.
STAR protocols 3(1) 101134
Glial and myeloid heterogeneity in the brain tumour microenvironment.
Nature reviews. Cancer 21(12) 786-802
Functional immune cell-astrocyte interactions.
The Journal of experimental medicine 218(9)
Role of sphingolipid metabolism in neurodegeneration.
Journal of neurochemistry 158(1) 25-35
Barcoded viral tracing of single-cell interactions in central nervous system inflammation.
Science (New York, N.Y.) 372(6540)
Gut-licensed IFNγ(+) NK cells drive LAMP1(+)TRAIL(+) anti-inflammatory astrocytes.
Nature 590(7846) 473-479
Astrocyte Crosstalk in CNS Inflammation.
Neuron 108(4) 608-622
Negative feedback control of neuronal activity by microglia.
Nature 586(7829) 417-423
AHR is a Zika virus host factor and a candidate target for antiviral therapy.
Nature neuroscience 23(8) 939-951
Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS.
Cell 179(7) 1483-1498.e22
Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39.
Nature neuroscience 22(5) 729-740
Role of AHR and HIF-1α in Glioblastoma Metabolism.
Trends in endocrinology and metabolism: TEM 28(6) 428-436
TNFa/TNFR2 signaling is required for glial ensheathment at the dorsal root entry zone.
PLoS genetics 13(4) e1006712
