
Defining rare cellular partners
Biomarker-guided microfluidics help the lab isolate rare transcriptional or genetically defined cell states from complex tissues, turning sparse signals into testable biology.
The Wheeler LabWhat We Do
The lab develops and applies experimental platforms to identify cellular partners, record transient interactions, and define how immune signaling tunes CNS function.


Biomarker-guided microfluidics help the lab isolate rare transcriptional or genetically defined cell states from complex tissues, turning sparse signals into testable biology.

Barcoded tracing and perturbation strategies reveal transient cellular circuits in the central nervous system that would otherwise disappear in bulk assays.

Genomics, spatial transcriptomics, imaging, deep learning, actuator technologies, and behavioral paradigms are combined to study immune control of neural function.

The lab studies how commensal flora, peripheral immune licensing, diet, pollutants, and stress tune astrocyte and CNS responses in health and disease.